health $wellness blog

Italy: A recent study published in the European Journal of Pediatrics has shown continuous glucose monitoring (CGM) to be a promising tool for individualizing nutritional strategies in preterm infants during the first weeks of birth. The study found that macronutrient intakes influence neonatal glucose profile as described by CGM and might contribute to adjusting nutritional intakes in preterm infants. "Continuous glucose monitoring describes the relationship between the intake of daily parenteral nutrients and time spent in hypo and hyperglycemic ranges," the researchers reported. Preterm infants, born before 37 weeks of gestation, often face numerous challenges in adapting to extrauterine life, including the regulation of blood sugar levels or glycemic homeostasis. Adequate nutrition has a pivotal role in supporting their growth and development, with macronutrients such as carbohydrates, proteins, and fats being key components of their diet. Recent advancements in med...

A new study sheds light on the impact of delayed appendicitis diagnosis on hospital care costs, revealing implications for healthcare reimbursement policies and disparities in patient care. Delayed diagnosis of appendicitis is associated with adverse outcomes, prolonged hospital stays, and increased likelihood of readmissions. Despite evidence of disparities in diagnosis rates, hospitals serving minority populations often receive lower reimbursement, raising concerns about equitable healthcare quality metrics. This study was published in the journal JAMA Network Open . The study was conducted by Kulaskera and colleagues. Researchers conducted a retrospective cohort study of 76,173 patients aged 18-64 who underwent appendectomy across multiple states in the US. The study analyzed data from 2016 to 2017, focusing on the association between delayed appendicitis diagnosis and hospital care costs. Patients with delayed diagnosis were identified based on prior abdominal diagnoses without...

New Delhi:  Doctors are hopeful about the recent move by the National Medical Commission (NMC), asking medical colleges across the country to submit the details of stipends paid to the MBBS interns and resident doctors. Hailing the move, the members of the medical fraternity have expressed their hope that this move will bring transparency as the medical colleges will now have to reveal the status of the stipend paid to the doctors. Medical Dialogues had been reporting about the complaints from MBBS interns and resident doctors alleging that they were not receiving stipend or receiving a meagre amount despite working in the hospitals round the clock. These complaints mainly come from medical students belonging to the private medical colleges.  Recently, the National Medical Commission (NMC) asked the medical colleges to submit the details of the stipend paid to their UG Interns, Post-Graduate Residents, and Senior Residents or PGs in Super Specialty for the financial year 20...

New Delhi: Reviewing the justification for waiver of the Phase III clinical trial of the anti-cancer drug Abiraterone Acetate presented by BDR Pharmaceutical Int, the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has reiterated earlier recommendations to conduct Phase III clinical trial. This came after BDR Pharmaceutical Int presented justification for waiver of the Phase III clinical trial before the committee. The firm informed that the proposed drug formulation Abiraterone Acetate Oral Suspension 1000mg/5ml has not yet been approved anywhere. The committee opined that the proposed formulation does not come under clinical trial waiver criteria i.e. unmet medical need, orphan drug status, or indicated serious life-threatening disease. Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumor tissues, to regulate ...

Remdesivir may lower the risk of in-hospital death among COVID-19 patients not requiring oxygen suggests a new study published in the Open Forum Infectious Diseases. Use of Remdesivir was linked to a significant decline in in-hospital death at both 14 and 28 days, regardless of variant of concern. Remdesivir has demonstrated benefit in some hospitalized patients with COVID-19 on supplemental oxygen and in non-hospitalized patients at room air. The durability of this benefit across time periods with different circulating SARS-CoV-2 variants of concern (VOC) is unknown. This comparative effectiveness study compares inpatient mortality among patients hospitalized for COVID-19 not receiving supplemental oxygen at admission initiating remdesivir treatment in the first two days of admission vs. no remdesivir during the hospitalization across different VOC periods. Using a large, multicenter US hospital database, in-hospital mortality was compared among patients hospitalized for COVID-19 n...

New Delhi: The drug major Dr Reddy's Labs has got a go-ahead from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) to manufacture and market the anti-cancer drug Lenalidomide capsules 20mg (additional strength) with Phase-III clinical trial (CT) waiver. This came after Dr.Reddy’s Labs presented the proposal for manufacturing and marketing permission for Lenalidomide capsules 20mg (additional strength) along with justification for the waiver of Phase-III CT with Bioequivalence study report of Lenalidomide capsules 25mg before the committee. The firm has informed that the proposed formulation strength 5mg 10 mg, 15mg, and 25 mg of Lenalidomide Capsules 20mg are already approved by CDSCO since 2007 in the country. The proposed strength 20 mg of Lenalidomide capsules are only for dose titration purposes only. Lenalidomide is a thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate-risk myel...

DNA analysis of saliva may predict treatment response and relapse in oral cancer patients suggests a new study published in the Oral Oncology. The incidence of head and neck squamous cell carcinoma (HNSCC) continues to increase and although advances have been made in treatment, it still has a poor overall survival with local relapse being common. Conventional imaging methods are not efficient at detecting recurrence at an early stage when still potentially curable. The aim of this study was to test the feasibility of using saliva to detect the presence of oral squamous cell carcinoma (OSCC) and to provide additional evidence for the potential of this approach. Fresh tumor, whole blood and saliva were collected from patients with OSCC before treatment. Whole exome sequencing (WES) or gene panel sequencing of tumor DNA was performed to identify somatic mutations in tumors and to select genes for performing gene panel sequencing on saliva samples. Results: The most commonly mutated gene...