health $wellness blog

Norway: Recent case reports in the Journal of Endodontics have highlighted the rare but serious risk of anaphylaxis following treatment with endodontic materials containing polyethylene glycol (PEG). Two patients experienced severe allergic reactions after dental procedures involving these materials, raising important concerns within the dental community. "While rare, clinicians should be aware that PEG in endodontic filling materials can trigger anaphylaxis. It is important to conduct a PEG allergy assessment when anaphylaxis is suspected," the researchers wrote. Anaphylaxis is a life-threatening allergic reaction that can occur rapidly, making early recognition and treatment critical. While anaphylactic reactions to PEG are uncommon, they are likely underreported and can lead to severe consequences for patients, especially those who remain undiagnosed. These cases emphasize the need for heightened awareness among dental professionals regarding the potential for PEG to ...

USA: A recent multicenter, retrospective, single-arm observational study has unveiled promising results for the use of droxidopa in critically ill patients experiencing persistent hypotension. The study, published in the Journal of Intensive Care Medicine, suggested that droxidopa may be a valuable adjunct therapy for facilitating vasopressor weaning, with comparable effects observed in patients receiving the medication through feeding tubes. Persistent hypotension is a significant challenge in the management of critically ill patients, often leading to prolonged reliance on vasopressor agents. These medications can have adverse effects and complications, underscoring the need for alternative strategies to facilitate safe withdrawal. According to the study authors, persistent reliance on vasopressors is a frequent factor contributing to delays in patient discharge from the intensive care unit (ICU). They note that adjunct oral agents can accelerate the timeline for discontinuing ...

Denmark: A recent study has highlighted a concerning association between the dosage of hormones in levonorgestrel-releasing intrauterine systems (LNG-IUS) and the risk of developing depression among first-time users. The research, published in the American Journal of Psychiatry, reveals that the likelihood of experiencing depression increases with higher dosages of the hormone, suggesting a dose-dependent relationship. The findings revealed that the first-time use of an LNG-IUS was associated with an increased risk of developing depression in a dose-dependent manner across low, medium, and high-dose options.  "While the observational nature of the study does not allow for causal conclusions, the identified dose-response relationship adds to the growing body of evidence indicating a link between levonorgestrel exposure and depression risk," the researchers wrote. Levonorgestrel, a synthetic progestin commonly used in various contraceptive methods, has been the subject of...

Karnataka: Shilpa Medicare Limited's 100% subsidiary, Shilpa Pharma Lifesciences Limited has received certificate of suitability (CEP) from EDQM (European Directorate for the Quality of Medicines & Healthcare) for API, Desmopressin. Desmopressin is synthetic peptide manufactured by Shilpa Pharma Lifesciences through solid phase synthesis. Desmopressin helps to reduce frequent urination and excessive thirst. This is used to treat central diabetes insipidus and bedwetting. “We at Shilpa have always been investing in challenging chemical synthesis. With unwavering commitment and belief in our technical capabilities, we have invested in developing a versatile peptide portfolio over past few years and Desmopressin is the first peptide molecule to receive CEP from the European Regulators. This CEP showcases our proficiency in quality-oriented development as well as commercial manufacturing capabilities that meet the expectations of global quality standards paving way for more suc...

Puducherry- The Centralised Admission Committee (CENTAC) has recently published the schedule and Draft Merit list for BSMS, BHMS and BUMS courses on its official website. The draft Merit list is prepared based on the National Eligibility and Entrance Test-Undergraduate (NEET UG) 2024 score. In this regard, CENTAC has published a notice informing that the objections if any, may be submitted through Grievances in the login dashboard or email on or before 07 October 2024, 11.00 am. No, objections will be allowed after the last date. After disposing of the objections, if any, the Final Merit List will be published on 07 October 2024. Meanwhile, physical Counselling for BSMS, BHMS and BUMS courses is scheduled on Tuesday, 08 October 2024 at 11.00 a.m. at CENTAC Office, Puducherry. Along with this, CENTAC has also released the seats available for the BSMS, BHMS and BUMS courses. As per the seats matrix, a total of 5 seats are available in the said courses for the academic year 2024. Of...

New Delhi: The Indian Pharmacopoeia Commission (IPC), through its recently issued drug safety alert for the month of September, has revealed that the popular antibiotic Tetracycline is linked with adverse drug reactions (ADRs) named Fixed Drug Eruption (FDE). In connection with the above, the Indian Pharmacopoeia Commission (IPC) has cautioned healthcare professionals to diligently monitor the potential occurrence of adverse drug reactions (ADRs) when administering tetracycline. This came after a preliminary analysis of adverse drug reactions (ADRs) from the Pharmacovigilance Programme of India (PvPI) database. Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversibly to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome accept...

Iran: A recent spanning eight years has shed light on the key factors contributing to post-surgical hypocalcemia (< 8.5 mg/dl) in laryngectomy patients. "Although average calcium levels showed no significant change, adjusting for albumin levels revealed a decrease in postoperative calcium. Total thyroidectomy, neck dissection, pre-operative hypocalcemia, and prior radiotherapy emerged as robust predictors of post-laryngectomy hypocalcemia," the researchers reported in the Indian Journal of Otolaryngology and Head & Neck Surgery. Laryngeal cancer represents a prevalent form of advanced head and neck malignancy. Treatment typically involves surgery, radiation therapy, chemotherapy, or a combination thereof, for managing locally advanced cases. Despite its invasive nature, total laryngectomy is commonly recommended for T3-4 laryngeal cancers. Following neck compartment surgeries like laryngectomy, patients are susceptible to post-surgical hypocalcemia due to the poten...